Underlying chronic granulomatous disease in a patient with bronchocentric granulomatosis.

نویسندگان

  • Y Moltyaner
  • W H Geerts
  • D W Chamberlain
  • P G Heyworth
  • D Noack
  • J Rae
  • J J Doyle
  • G P Downey
چکیده

We present a case of bronchocentric granulomatosis in a woman with no history of asthma who was colonised with Aspergillusfumigatus. A family history of chronic granulomatous disease prompted further testing that demonstrated severely depressed neutrophil oxidant production and gp91(phox) deficiency compatible with the X linked carrier state of chronic granulomatous disease. Only one report of the association of these two rare diseases has previously appeared in the literature. We postulate that an ineffective immune response led to the prolonged colonisation of Afumigatus resulting in a hypersensitivity reaction that was manifest clinically as bronchocentric granulomatosis.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

CASE REPORT Underlying chronic granulomatous disease in a patient with bronchocentric granulomatosis

We present a case of bronchocentric granulomatosis in a woman with no history of asthma who was colonised with Aspergillus fumigatus. A family history of chronic granulomatous disease prompted further testing that demonstrated severely depressed neutrophil oxidant production and gp91 deficiency compatible with the X linked carrier state of chronic granulomatous disease. Only one report of the a...

متن کامل

Idiopathic Granulomatosis Mastitis, Time to a Paradigm Change in Treatment

Idiopathic granulomatous mastitis (IGM) is among the chronic diseases of the breast, which is more common in Middle Eastern countries than in Western countries. Since the etiology of the disease is not well known, there is no international consensus on the management of the disease. Antibiotic, Non-Steroidal anti-inflammatory drugs (NSAIDs), corticosteroids, cytotoxic and immunosuppressive medi...

متن کامل

Bronchocentric granulomatosis and central diabetes insipidus successfully treated with corticosteroids.

Bronchocentric granulomatosis (BCG) is a rare chronic granulomatous lung disease that leads to destruction of the airway walls. It has been observed in association with various conditions, but never, so far, been reported to involve the central nervous system. We report a case of histologically confirmed pulmonary bronchocentric granulomatosis temporally associated with a partial central diabet...

متن کامل

Chronic Necrotizing Bronchopulmonary Aspergillosis With Elements of Bronchocentric Granulomatosis

Chronic necrotizing pulmonary aspergillosis (CNPA) is an unusual form of pulmonary aspergillosis arising in the setting of mildly immune compromised state or altered local defense system. CNPA rarely shows histological findings mimicking bronchocentric granulomatosis (BCG), which is characterized by peribronchiolar granulomatous destruction. We describe a case representing CNPA with elements of...

متن کامل

Progressive bronchocentric granulomatosis: case report.

Bronchocentric granulomatosis was first described in 19731 and is characterised by a necrotising granulomatous destruction of bronchial walls, bronchioles, and adjacent lung parenchyma. The bronchial lumen is filled by debris and cells, predominantly eosinophils in asthmatic patients and polymorphonuclear leucocytes in non-asthmatic patients.2 Proximal bronchi may show severe chondritis. Any va...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Thorax

دوره 58 12  شماره 

صفحات  -

تاریخ انتشار 2003